My guess would be that the Harvard-Penn line might skew a bit toward Harvard (maybe to a PK open) because in these types of situations, they try to move off the true line to make up for the fact that the general betting public might see "better seed an underdog to worse seed" and money might come in unevenly at true odds. And while Vegas usually tries to give the fair line because that's what's most likely to make the money fall evenly (what they want), in situations where they know things will be perceived a certain way, they shade that way to try to get that money to fall evenly.

But Penn is, indeed, a -1.5 or so favorite here.